This website collects cookies to deliver better user experience. Cookie Policy
Accept
Sign In
The Wall Street Publication
  • Home
  • Trending
  • U.S
  • World
  • Politics
  • Business
    • Business
    • Economy
    • Real Estate
    • Markets
    • Personal Finance
  • Tech
  • Lifestyle
    • Lifestyle
    • Style
    • Arts
  • Health
  • Sports
  • Entertainment
Reading: Toronto firefighter again on the job after new drug slows ‘incurable brain cancer’
Share
The Wall Street PublicationThe Wall Street Publication
Font ResizerAa
Search
  • Home
  • Trending
  • U.S
  • World
  • Politics
  • Business
    • Business
    • Economy
    • Real Estate
    • Markets
    • Personal Finance
  • Tech
  • Lifestyle
    • Lifestyle
    • Style
    • Arts
  • Health
  • Sports
  • Entertainment
Have an existing account? Sign In
Follow US
© 2024 The Wall Street Publication. All Rights Reserved.
The Wall Street Publication > Blog > World > Toronto firefighter again on the job after new drug slows ‘incurable brain cancer’
World

Toronto firefighter again on the job after new drug slows ‘incurable brain cancer’

Editorial Board Published October 24, 2024
Share
Toronto firefighter again on the job after new drug slows ‘incurable brain cancer’
SHARE

In December 2020, Steven Stefanidis, a 36-year-old firefighter from Toronto, was responding to a medical name when he blacked out and had a seizure.

After being assessed by first responders, he was taken to the hospital, the place an MRI revealed a tumour. It was identified as a Grade 2 IDH-mutant glioma, an incurable type of mind most cancers.

“Here I was in my early 30s, living my best life with a dream job when I suddenly had a seizure. I can’t describe what it was like to be told that I had an incurable brain cancer,” he stated.

“At first I was in shock and I wasn’t digesting the information because it’s heavy. But overall, the neurosurgeon that I met was very relaxed and confident and I trusted him and he put me in a good situation. I didn’t freak out or anything. I knew I was in good hands at the moment.”

Story continues under commercial

He later underwent surgical procedure to alleviate his signs, which occurred one week after his analysis.

Steven Stefanidis after his mind surgical procedure. Steven Stefanidis

Stefanidis is likely one of the hundreds of Canadians identified with mind and spinal twine most cancers yearly, in accordance with the Canadian Most cancers Society. The kind he has, gliomas, is the second-most widespread most cancers amongst Canadians underneath 40 and the second-leading reason behind cancer-related deaths on this age group.

And IDH-mutant glioma often arises in folks of their 30s and 40s, when they’re within the prime of their lives — working and elevating households, defined Dr. Mary Jane Lim-Fats, neurologist and neuro-oncologist at Sunnybrook Well being Sciences Centre.

Story continues under commercial

However there may be hope. A brand new oral remedy known as Voranigo has been proven to focus on mind tumours, and in Part 3 medical trials, to “significantly” sluggish their progress. Stefanidis participated in these medical trials at Sunnybrook Well being Sciences Centre in Toronto, and he stated the remedy has been efficient for his most cancers.

“Since receiving the treatment during the clinical trials… there’s no side effects from the medication, and on the positive side, we’ve noticed stabilization and some shrinkage in the remaining [tumour],” he stated.

Steven Stefanidis is photographed on the Odette Most cancers Centre at Sunnybrook Well being Sciences Centre Might 24, 2023. by Kevin Van Paassen/Sunnybrook

And now it has formally been authorized in Canada.

Receive the latest medical news and health information delivered to you every Sunday.

Get weekly well being information

On Tuesday, Well being Canada introduced the approval of Voranigo, the primary focused remedy for treating Grade 2 isocitrate dehydrogenase (IDH)-mutant glioma in adults and pediatric sufferers aged 12 and older, following surgical procedure. It’s Canada’s first oral focused remedy for mind most cancers.

Story continues under commercial

Drug slowed development of tumour

Voranigo was studied in a large-scale, randomized, placebo-controlled medical trial with sufferers from around the globe, together with Canada, from January 2020 via February 2022.

The outcomes of the Part 3 medical trials have been printed in June 2023 within the New England Journal of Medication, and present promising outcomes, Lim-Fats stated.

“This new drug essentially is a brain penetrant oral drug that patients can take by mouth that alters the function of that mutant protein. So in doing that, it slows down the growth of the tumour, stabilizes it in some instances, and even decreases the growth or shrinks the tumours in some cases,” she stated.

So what precisely does this imply?

Gliomas are troublesome to deal with and infrequently progress to extra aggressive types of mind most cancers, partly because of the blood-brain barrier. This protecting layer shields the mind from hurt but additionally makes it difficult for therapies to penetrate and successfully goal tumours, Lim-Fats defined.

Story continues under commercial

Because of the blood-brain barrier, the present remedy for gilomas entails a mix of surgical procedure, adopted by radiation and chemotherapy. Whereas these remedies can briefly halt the tumour’s progress, Lim-Fats famous that it will definitely returns.

Click to play video: 'Montreal mother desperate to access treatment for rare brain tumor'

2:45Montreal mom determined to entry remedy for uncommon mind tumor

Trending Now

After Financial institution of Canada’s outsized minimize, is decrease and quicker the brand new tempo?

Lady discovered lifeless in oven at Halifax Walmart situated by her mom, group says

However Voranigo is particularly designed to cross the blood-brain barrier and attain the mind to focus on mutated enzymes which might be inflicting the most cancers.

Part 3 medical trial outcomes present that the drug greater than doubled the time earlier than the tumour grew again in sufferers. It additionally delayed the necessity for interventions like chemotherapy and radiation, which include extreme unwanted effects.

“The median progression-free survival for patients who were on placebo — so did not receive anything — was roughly about 11.1 months. But when they looked at the group that got [Voranigo], that progression-free survival, that delay was more than double that time, it was 27.7 months,” Lim-Fats stated.

Story continues under commercial

“These results in and of themselves are very encouraging and showed that this drug was actually quite good at delaying that progression in these patients.”

‘Major breakthrough’ in most cancers remedy

Now that Voranigo is authorized in Canada, Stefanidis stated he hopes the remedy will help others who’re in the identical scenario.

After taking day without work work, he’s now again on the job as a firefighter and has even began touring, exercising and mountaineering once more.

“I feel like a regular, normal, healthy adult. I’m slowly back to my regular day-to-day routine. I’m back to work now, fully back on the fire trucks responding. And it feels great to be back on with the same crew,” he stated.

“I just recently had my first vacation in July of this year. And it felt amazing just to get out there. And that’s another thing about this medication. It’s not something where I had to stay within my area because I could only get the treatment there. I’m able to carry this with me wherever I go and use it as like a mobile treatment,” he added.

Story continues under commercial

After taking time of labor for his most cancers analysis, Stefanidis is again on the job. Steven Stefanidis

Stefanidis stated he takes it as soon as each morning, just like a multivitamin, and retains observe of it in his diary for dosage and time.

Lim-Fats expressed that the oncology neighborhood is really excited concerning the approval of this drug in Canada, saying, “We haven’t had a breakthrough like this in terms of a new drug in about 20 years.”

Nevertheless, she famous that some questions stay. Medical doctors nonetheless don’t know the long-term survival outcomes for sufferers taking the drug, or whether or not sure teams of sufferers would possibly reply higher or longer to the remedy.

“But nonetheless, we think it is a major breakthrough and major advancement in terms of providing more options for patients,” she stated.

Extra on HealthMore movies

TAGGED:BraincancerdrugfirefighterincurablejobslowsToronto
Share This Article
Twitter Email Copy Link Print
Previous Article 7 Greatest Compression Underwear For Males In 2024 | Fashion 7 Greatest Compression Underwear For Males In 2024 | Fashion
Next Article 87-year-old girl badly injured in Oakland theft; three teen suspects later arrested 87-year-old girl badly injured in Oakland theft; three teen suspects later arrested

Editor's Pick

Alyssa Farah Griffin: ‘The View’ Co-Host is Pregnant With Child #1!

Alyssa Farah Griffin: ‘The View’ Co-Host is Pregnant With Child #1!

Studying Time: 3 minutes The View co-host Alyssa Farah Griffin is pregnant! On ‘The View,’ Alyssa Farah Griffin breaks the…

By Editorial Board 3 Min Read
Arturo Gatti Jr. Reason behind Dying: Son of Boxing Legend Passes Away at 17
Arturo Gatti Jr. Reason behind Dying: Son of Boxing Legend Passes Away at 17

Studying Time: 2 minutes Aruturo Gatti Jr. — an aspiring boxer and…

3 Min Read
Mandy Moore ‘Unrecognizable’ to Followers After Debuting New Face
Mandy Moore ‘Unrecognizable’ to Followers After Debuting New Face

Studying Time: 4 minutes Mandy Moore has followers scratching their heads. This…

6 Min Read

Oponion

Rihanna Pregnant: Her Journey To Welcoming Child #3 Revealed

Rihanna Pregnant: Her Journey To Welcoming Child #3 Revealed

Studying Time: 5 minutes Is Rihanna pregnant and welcoming child…

April 16, 2025

Effort to Hire Dallas and Boston Fed Leaders Hits Full Stride

The search to replace two regional…

November 18, 2021

Prep roundup: Jasir Rencher’s clutch shot lifts Riordan over Salesian to win Gridley Invitational Match

No. 2 Archbishop Riordan 52, No.…

December 15, 2024

Google Maps Chief Sees New Directions for Digital Navigation

What’s the weather at the cafe?…

December 28, 2022

Single-family residence in Pleasanton sells for $1.7 million

3635 Platt Courtroom – Google Avenue…

April 3, 2025

You Might Also Like

Former state senator agrees to pay practically K to settle marketing campaign finance violations surfaced by Colorado Solar
World

Former state senator agrees to pay practically $3K to settle marketing campaign finance violations surfaced by Colorado Solar

Former state Sen. Sonya Jaquez Lewis, a Longmont Democrat, has agreed to pay practically $3,000 to the Colorado Secretary of…

5 Min Read
‘Make or break’: Chancellor warned companies cannot take extra tax hikes in price range | UK Information
World

‘Make or break’: Chancellor warned companies cannot take extra tax hikes in price range | UK Information

Rachel Reeves has been warned that companies face a “make-or-break moment” at subsequent month’s price range. The British Chamber of…

5 Min Read
GP shares 4 dietary staples he eats ‘each single day’ to chop his danger of the illness
World

GP shares 4 dietary staples he eats ‘each single day’ to chop his danger of the illness

Western nations face a very powerful battle with colon most cancers, with poor consuming habits forming a big a part…

3 Min Read
A Dynasty star and the Thatcher dynasty | Politics Information
World

A Dynasty star and the Thatcher dynasty | Politics Information

It was the night time I rescued Dame Joan Collins’ silk night glove. The star of TV’s Dynasty and numerous…

4 Min Read
The Wall Street Publication

About Us

The Wall Street Publication, a distinguished part of the Enspirers News Group, stands as a beacon of excellence in journalism. Committed to delivering unfiltered global news, we pride ourselves on our trusted coverage of Politics, Business, Technology, and more.

Company

  • About Us
  • Newsroom Policies & Standards
  • Diversity & Inclusion
  • Careers
  • Media & Community Relations
  • WP Creative Group
  • Accessibility Statement

Contact

  • Contact Us
  • Contact Customer Care
  • Advertise
  • Licensing & Syndication
  • Request a Correction
  • Contact the Newsroom
  • Send a News Tip
  • Report a Vulnerability

Term of Use

  • Digital Products Terms of Sale
  • Terms of Service
  • Privacy Policy
  • Cookie Settings
  • Submissions & Discussion Policy
  • RSS Terms of Service
  • Ad Choices

© 2024 The Wall Street Publication. All Rights Reserved.

Welcome Back!

Sign in to your account

Lost your password?