A brand new examine from the UConn College of Drugs has revealed that walnuts might play a major function in lowering colorectal most cancers threat.
The analysis, revealed in Most cancers Prevention Analysis, discovered that compounds known as ellagitannins present in walnuts assist inhibit most cancers growth.
These useful compounds are transformed by the intestine into urolithin A, a potent anti-inflammatory agent.
“Ellagatannins in the walnut are importantly providing the anti-inflammatory and anticancer properties that we’re seeing in patients in our clinical trial research,” mentioned examine writer Daniel W. Rosenberg from the UConn College of Drugs.
Bowel most cancers sufferers typically report persistent abdomen painGETTY
The examine included 39 sufferers between the ages of 40 and 65 who have been screened at UConn John Dempsey Hospital.
Contributors first averted all ellagitannin-containing meals and drinks for per week to reset their urolithin ranges.
They then started consuming ellagitannin-rich walnuts as a part of a carefully monitored eating regimen. After three weeks on this eating regimen, every participant underwent a colonoscopy.
Researchers have been in a position to measure the consequences of walnut consumption on colon well being by inspecting tissue samples and biomarkers.
The outcomes confirmed that sufferers with excessive ranges of urolithin A following walnut consumption had lowered ranges of a number of essential proteins typically current in polyps.
These polyps are small growths that type on the liner of the colon and may result in colorectal most cancers. Excessive urolithin A ranges additionally lowered inflammatory markers throughout blood, urine, and faecal samples.
The researchers famous these results may positively affect immune cells inside colon polyps.
Sufferers with elevated urolithin A ranges additionally confirmed elevated serum ranges of peptide YY, a protein related to the inhibition of colorectal most cancers.
Walnuts provide a variety of well being advantages
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The protein vimentin, typically linked to superior types of colon most cancers, was considerably lowered in polyp tissues of sufferers with the best urolithin A ranges.
Apparently, the examine discovered that sufferers with weight problems had the best capability to type urolithins by means of their intestine microbiome.
“Urolithin A has a very positive influence on inflammation and maybe even cancer prevention,” Rosenberg defined.
He famous that dietary supplementation with walnuts can increase urolithin ranges in folks with the precise microbiome, while considerably lowering inflammatory markers, particularly in overweight sufferers.
“There are many potential benefits one can get from eating walnuts, with so little downside risk,” Rosenberg added.
“Just grabbing a handful every day is really something that you can easily do for your long-term health benefit.”
